(Optional) Hosting CryoSPARC Through a Reverse Proxy

As discussed in Accessing the CryoSPARC User Interface, there are various ways in which users can access the CryoSPARC web interface such as through a VPN connection or SSH tunnel. If you would like to host the CryoSPARC interface in a secure manner at a predictable URL, this can be done through a reverse proxy server.

Reverse proxy servers allow for more control over how a user accesses a web application interface over other methods. By controlling incoming network traffic it is able to host the application at a static URL (for example https://cryosparc.institution.edu) and ensure all correspondence is secured via HTTPS.

The method in which you host CryoSPARC through a reverse proxy is similar to hosting any other web application. However, the following serve as our recommended minimum requirements:

• All incoming traffic should be served through HTTPS (via a SSL certificate)

• HTTPS traffic requires a valid SSL certificate provided by a certificate authority (CA) for the domain in which you are hosting the interface.

• If the server listens for incoming HTTP traffic, forward all connections to a more secure protocol (HTTPS)

• Ensure traffic is also mediated by an organization-level authentication barrier (for example single sign-on). CryoSPARC should not be served via the public internet without any additional authentication checks.

There are many ways to generate a SSL certificate for your domain, however, this will most likely be specific to your institution or organization. If you're unsure of how to generate a SSL certificate for your private network, please consult with your system or network administrator for guidance.

Each institution or private network can have a specific setup requiring custom rules and/or proxy configuration considerations. Generally the example configurations below should be compatible with common reverse proxy installations. Please consult with your system or network administrator for guidance regarding institution-specific protocols for reverse proxy hosting.

The following section will provide example configuration files for common reverse proxy servers given CryoSPARC is running on base port 61000.

NGINX

This NGINX configuration takes advantage of authenticated origin pulls for an added layer of security between the reverse-proxy and a downstream proxy/load balancer.

server {
  listen 80;
  listen [::]:80;
  server_name private.domain.dev;
  return 302 https://$server_name$request_uri;
}

server {
  # SSL configuration
  listen 443 ssl http2;
  listen [::]:443 ssl http2;
  ssl        on;
  ssl_certificate         /etc/certs/domain.dev/origin-cert.pem;
  ssl_certificate_key     /etc/certs/domain.dev/private-key.pem;
  ssl_client_certificate  /etc/certs/domain.dev/origin-pull-ca.pem;
  ssl_verify_client on;

  server_name   private.domain.dev;
  access_log    /var/log/nginx/private.domain.dev.access.log;
  error_log     /var/log/nginx/private.domain.dev.error.log;

  location / {
    proxy_pass http://127.0.0.1:61000;
    proxy_http_version 1.1;
    proxy_set_header Upgrade $http_upgrade;
    proxy_set_header Connection 'upgrade';
    proxy_set_header X-Forwarded-For $remote_addr;

    proxy_request_buffering  off;
    proxy_buffering          off;
    client_max_body_size     0;
  }
}

An alternative configuration from our Discussion Forum that serves the application over HTTPS and redirects incoming HTTP requests.

server {
  listen                80;
  server_name           <YOUR_URL>;

  access_log            /var/log/nginx/<YOUR_URL>.http.access.log;
  error_log             /var/log/nginx/<YOUR_URL>.http.error.log;

  location / {
    return 301 https://$server_name$request_uri;
  }
}


server {
  listen                443 ssl;

  server_name           <YOUR_URL>;

  access_log            /var/log/nginx/<YOUR_URL>.access.log;
  error_log             /var/log/nginx/<YOUR_URL>.error.log;

  location / {
    proxy_pass http://127.0.0.1:61000;
    proxy_http_version 1.1;
    proxy_set_header Upgrade $http_upgrade;
    proxy_set_header Connection 'upgrade';
    proxy_set_header X-Forwarded-For $remote_addr;

    proxy_request_buffering  off;
    proxy_buffering          off;
    client_max_body_size     0;
  }
  ssl_certificate /etc/letsencrypt/live/<YOUR_URL>/fullchain.pem; # managed by Certbot
  ssl_certificate_key /etc/letsencrypt/live/<YOUR_URL>/privkey.pem; # managed by Certbot
}

Apache

The following is a simplified Apache HTTP Server configuration that illustrates the RewriteRule. For production use, we recommend HTTPS instead of HTTP. Additional configuration, not shown here, is required to enable HTTPS.

<VirtualHost *:80>
	ProxyRequests Off
	RewriteEngine on
	ProxyPass / http://localhost:61000/
	ProxyPassReverse / http://localhost:61000/
	RewriteCond %{HTTP:UPGRADE} ^WebSocket$ [NC]
	RewriteCond %{HTTP:CONNECTION} ^Upgrade$ [NC]
	RewriteRule .* ws://localhost:61000%{REQUEST_URI} [P]
</VirtualHost>