Introduction

Cryo-EM Single Parcticle Ab initio Reconstruction and Classification (cryoSPARC)

CryoSPARC is a software package for processing single-particle electron cryo-microscopy (cryo-EM) data. This Guide contains detailed information on installing, configuring and using cryoSPARC.

This Guide contains detailed information on installing, configuring and using cryoSPARC v0.2.47 to 0.6.5 only. For detailed documentation, installation instructions and a tutorial for cryoSPARC v2.0+, please visit our new documentation page.

  • For more information, visit cryosparc.com and structura.bio, or follow us on Twitter (@structurabio).
  • Our blog has the latest insights on cryo-EM data processing and getting the most out of cryoSPARC.
  • Troubleshooting and tips? See the Discussion Forum.
  • Log errors, issues and feature requests on the Issue Tracker.