# Job: MotionCor2 (Wrapper) (BETA)

## At a Glance

Perform motion correction using MotionCor2 as a wrapper within CryoSPARC.

## Description

MotionCor2 models the anisotropic motion of electron microscopy movies using a smooth deformation model. More details are available in Zheng, 2017.

Please ensure that you review the MotionCor2 License Terms before using it in your project.

### MotionCor2 License Terms

> CryoSPARC does not distribute MotionCor2 binaries. Please ensure you have your own copy of MotionCor2 installed under the terms of the MotionCor2 Non-Commercial Software License Agreement available at: <https://docs.google.com/forms/d/e/1FAIpQLSfAQm5MA81qTx90W9JL6ClzSrM77tytsvyyHh1ZZWrFByhmfQ/formResponse>.\
> \
> For-profit users must contact David Agard for licensing information prior to download. Structura Biotechnology Inc. makes no warranty regarding MotionCor2.

## Inputs

### Movies

MotionCor2 requires movies as an input, typically from an Import Movies job.

## Commonly Adjusted Parameters

### Patch Value

MotionCor2 requires users to input the number of patches in the X and Y axes. Note that this setting is distinct from Patch Motion Correction’s `knots` settings.

## Outputs

### Micrographs

MotionCor2 outputs motion-corrected micrographs.

## Common Next Steps

Micrographs typically require CTF estimation in [Patch CTF Estimation](https://guide.cryosparc.com/processing-data/all-job-types-in-cryosparc/ctf-estimation/job-patch-ctf-estimation) for further downstream processing.

## References

1. Zheng, S. Q. *et al.* MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy. *Nature Methods* **14**, 331–332 (2017).